产品应用
应用说明
*最佳稀释倍数与浓度应由研究人员确认
| 实验应用 |
稀释倍数 |
| Assay dependent |
| Assay dependent |
| Assay dependent |
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片
预期分子量
产品属性
形式
Liquid
存储溶液
PBS, 150mM NaCl, 50% Glycerol
存放说明
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
浓度
1 mg/ml (Please refer to the vial label for the specific concentration.)
免疫原种属
Human
免疫原
A synthesized peptide derived from human c-Met around the phosphorylation site of Tyr1234.
纯化方式
Purified by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns
From serum
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
相关讯息
别名
MET proto-oncogene, receptor tyrosine kinase , AUTS9 , DFNB97 , HGFR , RCCP2 , c-Met
细胞定位
Membrane; Single-pass type I membrane protein
功能与背景
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
数据库
研究领域
產品图片
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GTX02868 WB Image
WB analysis of extracts from mouse lung and rat kidney using GTX02868 c-Met (phospho Tyr1234) antibody. -/+ means absence or presence of N peptide(non-phospho peptide) and P peptide(phospho peptide).
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GTX02868 ICC/IF Image
ICC/IF analysis of PFA-fixed NIH-3T3 cells using GTX02868 c-Met (phospho Tyr1234) antibody.
Permeabilization : 0.1% Triton X-100
Dilution : 1:200
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GTX02868 WB Image
WB analysis of extracts from heat-shock treated EC304 cells using GTX02868 c-Met (phospho Tyr1234) antibody. The lane on the left was treated with blocking peptide.
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GTX02868 ELISA Image
ELISA analysis of phospho- and non phosho- immunogen peptide using GTX02868 c-Met (phospho Tyr1234) antibody.
P-peptide : phospho-peptide
N-peptide : non-phospho-peptide
Peptides concentration : 1μg/ml
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文献引用
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产品评论
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