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p53 (phospho Ser46)抗体 [#36]

Comparison Orthogonal
Anti-p53 (phospho Ser46) antibody [#36] used in IHC (Paraffin sections) (IHC-P). GTX00680
Anti-p53 (phospho Ser46) antibody [#36] used in Western Blot (WB). GTX00680
Anti-p53 (phospho Ser46) antibody [#36] used in Western Blot (WB). GTX00680
Anti-p53 (phospho Ser46) antibody [#36] used in Western Blot (WB). GTX00680

目录号 GTX00680

文献引用 3

宿主

 Mouse

克隆

 Monoclonal

克隆编号

 #36

同种型

 IgG1

实验应用

 WB, IHC-P, ELISA

种属反应

 Human
产品包装
100 μg (¥5600)
查看所有 p53 的产品

产品应用

应用说明

*最佳稀释倍数与浓度应由研究人员确认
实验应用 稀释倍数
WB 1:1000-1:2000
IHC-P Assay dependent
ELISA Assay dependent
WB: 免疫印迹
ICC/IF: 细胞染色
IHC-P: 石蜡切片
IHC-Fr: 冰冻切片

预期分子量

44 kDa. ( Note )

产品属性

形式

Liquid

存储溶液

Filter-sterilized PBS, 50% Glycerol

存放说明

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

浓度

1 mg/ml (Please refer to the vial label for the specific concentration.)

免疫原种属

Human

免疫原

Synthetic peptide containing phospho-Ser46 of p53

纯化方式

Purified IgG
From tissue culture supernatant

偶联

Unconjugated

注意事项

仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。

相关讯息

别名

tumor protein p53 , BCC7 , BMFS5 , LFS1 , P53 , TRP53

细胞定位

Cytoplasm,Nucleus,Endoplasmic reticulum,Mitochondrion matrix

功能与背景

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

数据库

研究领域

產品图片

Anti-p53 (phospho Ser46) antibody [#36] used in IHC (Paraffin sections) (IHC-P). GTX00680

GTX00680 IHC-P Image

IHC-P analysis of Human stomach cancer tissue section using GTX00680 p53 (phospho Ser46) antibody [#36].

Anti-p53 (phospho Ser46) antibody [#36] used in Western Blot (WB). GTX00680

GTX00680 WB Image

Comparison Orthogonal

WB analysis of MOLT-4 cells treated with/without adriamycin for 24 hrs using GTX00680 p53 (phospho Ser46) antibody [#36].
Left : GTX00680
Right : the competitor's p53 phospho-Ser46 antibody

Anti-p53 (phospho Ser46) antibody [#36] used in Western Blot (WB). GTX00680

GTX00680 WB Image

Orthogonal

WB analysis of various samples using GTX00680 p53 (phospho Ser46) antibody [#36] (upper panel) or anti-p53 antibody (lower panel).
Samples : U2OS cells were irradiated by X-ray (10 Gy) for 0, 0.5, 1, 2, and 4 hrs

Anti-p53 (phospho Ser46) antibody [#36] used in Western Blot (WB). GTX00680

GTX00680 WB Image

Orthogonal

WB analysis of various samples using GTX00680 p53 (phospho Ser46) antibody [#36] (upper panel) or anti-p53 antibody (lower panel).
Samples : MCF-7 cells were irradiated by UV (20 J/m2) for 0, 1, 2, 4, and 8 hrs

文献引用

Clone Reference

Taira N et al. J Biol Chem.? 2010; 285 (7):4909-19 ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
实验应用 : WB
种属反应 : Human
Kodama M et al. Mol Cell Biol. 2010; 30 (7):1620-33 Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
实验应用 : WB
种属反应 : Human
Taira N et al. Mol Cell. 2007; 25 (5):725-38 DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.
实验应用 : WB
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SDS
PBS.pdf
Glycerol.pdf
产品包装 报价 (¥)
¥ 5600
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