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Summary This antibody detects several members of the heat shock protein 70 kDa (HSP70) gene family including HSP70, HSC70, p75, and following heat shock, HSP72 from yeast, Drosophila, fish, porcine, plant, mouse, avian, arthropod (red claw crayfish and black tiger prawn), amphibian, non-human primate, and human samples. Epitope mapping with a panel of HSP70 deletion mutants suggests that the epitope recognized is located between amino acids 504-617 of human HSP70, a region that has been shown to be involved in stress-induced nucleolar localization.

RPA70 antibody [C1C3] Cat No. GTX108749

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KO/KD

Summary KO/KD validation is based on customer review data.

Caspase 3 antibody [31A1067] Cat No. GTX13585

3 引用文献

Orthogonal

Summary The antibody detects both pro Caspase-3 (~32 kDa) and the large subunit of the active/cleaved form (~14-21 kDa) of Caspase-3. The large subunit of the cleaved form may appear as one or two or even as a stack of bands depending on the presence or absence of the Caspase-3 pro-domain. It is highly recommended that a maximum sensitivity ECL substrate (Femto sensitive) be used for efficient detection of this antibody in Western blot applications.

Summary This antibody has been shown to partially block the proliferative response of antigen-specific CD4+ T cells to antigen-presenting cells and relevant antigen. (Stevenson, K.S. et al.2009)
This antibody is suitable for use in IHC-P pre-treated with 0.2M boric acid, pH7.0. (Wilson et al. 2007)
This antibody has been shown to be cross-reactive with endothelial cells derived from rhesus macaque (Maclean et al. 2001)