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Summary This antibody reacts with mouse Notch constructs present in lysates of HEK 293 cells. Only the cleaved intracellular (activated) form (NICD) is detected. No reactivity is detected against mouse N2, N3 or N4. The immunogen epitope is only exposed after gamma secretase cleavage and is not accessible in the uncleaved form.

ADAM17 antibody Cat No. GTX31632

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KO/KD

Summary 80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated form.

Summary No cross-reactivity is seen with presenilin 2. This antibody detects an ~18 kDa protein representing PS1 CT (C-terminus fragment) and the ~46 kDa full-length PS1 from transfected SH-SY5Y cells.

GSK3 beta (phospho Ser9) antibody Cat No. GTX29769

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Orthogonal

Summary This phospho specific polyclonal antibody reacts with phosphorylated pS9 of human GSK3B. Reactivity with non-phosphorylated human GSK3B is minimal.