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Summary The complete 145-2C11 antibody is commonly used to stimulate T cells in vitro however, when used in vivo activation of resting T cells results in cytokine release and toxicity caused by Ab-mediated cross-linking of T cells and Fcγ receptor-bearing cells. To avoid these complications non-Fc receptor binding F(ab’)2 fragments of the 145-2C11 antibody are commonly used. This non-FcR-binding anti-CD3 induces apoptosis of Ag-activated T cells in vivo  by allowing durable expression of the TCR and sustained signaling. Foxp3+ Tregs have been shown to be resistant to CD3 antibody-mediated depletion.

GBP5 antibody Cat No. GTX31537

1 引用文献

Orthogonal

Summary GBP5 antibody is predicted to not cross-react with other GBP family members.

DDX60 antibody Cat No. GTX32082

3 引用文献

KO/KD

Summary At least three isoforms of DDX60 are known to exist; this antibody will detect all three isoforms.

Summary This antibody reacts to both kappa and lambda light chains of human immunoglobulins. The antibody does not react to monkey (Cyno or Rhesus) IgG, mouse IgG, rat IgG, or goat IgG.