肠病毒D68型研究

Figure 1. The EV-D68 virion

The Enterovirus genus (family Picornaviridae) encompasses 15 species, though only seven of these (i.e., Enterovirus A to D and Rhinovirus A to C) include viruses that infect humans. Each species contains various “types”, with the Enterovirus D species having five of which two (Enteroviruses D68 (EV-D68) and D70 (EV-D70)) infect only humans. EV-D68 can cause severe respiratory disease and is linked to the neurologic syndrome acute flaccid myelitis (AFM) that overwhelmingly (>90%) affects children (1, 2). Though first described in 1962, it is over the last one to two decades that there has been an increasing worldwide incidence of EV-D68 cases that tracks with AFM outbreaks. The EV-D68 genome has evolved rapidly and is now categorized into four clades, with mutations that appear to have broadened tissue tropism and virulence (including neurovirulence). Presently there are no available vaccines or antiviral agents for these pathogens.

Enterovirus D viruses are small and non-enveloped with a single-stranded, positive-sense RNA genome that is translated into a single polyprotein subsequently processed into 11 mature proteins. These include the four structural proteins VP1, VP2, VP3, and VP4 in addition to seven nonstructural proteins (i.e., 2A, 2B, 2C, 3A, 3B, 3C and 3D) (2). Further characterization of their functions and host-viral factor interactions are essential for a better understanding of Enterovirus D pathogenesis.

GeneTex continues to expand its infectious disease catalog with a growing portfolio of reagents for non-poliovirus Enterovirus (NPVE) research (including antibodies against Coxsackievirus A6, Enterovirus A71, and Enterovirus D68). This includes the new recombinant rabbit monoclonal Enterovirus D68 VP1 antibody [HL1997] (GTX637898) for the EV-D68 product line. Please see the highlighted product images and a complete EV-D68 antibody listing below.

Figure 2. The EV-D68 genome codes for a single polyprotein that is processed into 11 mature proteins.

Featured Products

Enterovirus D68 VP1 antibody [HL1997] (GTX637898)	Enterovirus D68 VP1 antibody [GT11610] (GTX633688)	Capture: Enterovirus D68 VP1 antibody [GT11610] (GTX633688) Detection: Enterovirus D68 VP1 antibody [HL1997] (GTX637898)
Enterovirus D68 VP1 protein, His tag (GTX138561-pro)	Enterovirus D68 VP3 antibody [GT1665] (GTX633706)	Enterovirus D68 2B antibody (GTX134419)

Product Name Clonality Applications Cat. No.   Enterovirus D68 VP2 antibody Rb pAb WB, ICC/IF, IHC-Fr GTX132314 Enterovirus D68 VP3 antibody [GT1665] Ms mAb WB GTX633706 Enterovirus D68 VP3 antibody Rb pAb WB, IHC-P GTX132315 Enterovirus D68 VP1 antibody [HL1997] Rec Rb mAb WB, ELISA, Sandwich ELISA GTX637898   Enterovirus D68 VP1 antibody [GT11610] Rec Ms mAb WB, ELISA, Sandwich ELISA GTX633688   Enterovirus D68 VP1 antibody [GT1843] Ms mAb WB, IHC-P, ELISA GTX633770   Enterovirus D68 VP1 antibody Rb pAb WB, ICC/IF, IHC-P, FACS GTX132313   Enterovirus D68 VP1 antibody Rb pAb WB GTX132312 Enterovirus D68 2B antibody Rb pAb WB GTX134419

References:

1. J Virol.2022 Aug; 96(15): e00833-22.
2. Microorganisms.2021 Aug; 9(8): 1758.