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DNA甲基化

The three mammalian 5-methylcytosine (5-mC) dioxygenases (Ten Eleven Translocation (TET); TET1, TET2, and TET3 in humans) convert 5-mC to 5-hydroxymethylcytosine (5-hmC) and subsequently to 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). This series of modifications is thought to represent one pathway to active DNA demethylation, thereby reshaping the methylated DNA landscape established by DNA methyltransferases (DNMTs). In addition, these marks, particularly 5-hmC, have been shown to be distinct epigenetic signatures in their own right impacting stem cell and cancer cell biology.

GeneTex introduces a selection of antibodies to targets relevant to DNA methylation and demethylation. We are proud to note that many of these antibodies are suitable for ChIP/ (h)MeDIP application.

 

Highlighted Products

Citation-Support KOKD-Validation Orthogonal Validation Protein Overexpression 

TDG antibody (GTX110473)

TDG antibody (GTX110473)

DNMT1 antibody [N1], N-term (GTX116011)

DNMT1 antibody [N1], N-term (GTX116011)

TET2 antibody [N2-2], N-term (GTX124205)

TET2 antibody [N2-2], N-term (GTX124205)

 
DNMT3B antibody (GTX129127)

DNMT3B antibody (GTX129127)

SIN3A antibody (GTX129156)

SIN3A antibody (GTX129156)

TET1 antibody [GT1462] (GTX627420)

TET1 antibody [GT1462] (GTX627420)

 

 

 

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