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登革热病毒研究

登革热病毒研究

Dengue Virus
 
Dengue (DEN) is the most serious of the mosquito-borne viral diseases. It is caused by Dengue virus (DENV), from any of the four serotypes (DEN1-4). Patients develop long-term immunity to the initial infecting serotype. However, sequential infection by different serotypes leads to a greater risk of serious disease manifestations. From this observation emerged the hypothesis of antibody-dependent enhancement (ADE) of infection, whereby previously acquired anti-DENV antibodies appear to facilitate both higher viremia and amplified release of inflammatory mediators in response to heterotypic DENV infection. This may explain the epidemiological findings that infants born to DEN-immune mothers are at higher risk of more severe clinical disease. Now Ng et al (1), using an elegant mouse model system, offer compelling evidence in support of the ADE hypothesis in the mother-offspring scenario. They found that DENV2-infected offspring born to DENV1-immune mothers displayed more serious disease and died sooner compared to DENV2-infected mice born to naïve mothers. Notably, the susceptibility to disease was age-dependent, recapitulating the epidemiological observations. Taken together, this ADE mouse model joins a growing list of animal models of infectious disease, and will provide promising opportunities to further dissect the underlying mechanisms of Dengue pathogenesis.
 
The Dengue virus (DEN) is of the genus Flavivirus and possesses a positive-strand RNA genome of approximately 10.6 kb that contains a single open-reading frame encoding for a polyprotein, which can be further cleaved by cellular and viral proteases into three structural proteins (capsid protein C, membrane protein M, envelope protein E), and seven non-structural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5).
 
GeneTex proudly offers a comprehensive catalog of outstanding antibodies to DENV proteins. While most of these were created using recombinant antigens from DEN2, the majority are very likely to cross-react with the other serotypes. A few of the antibodies are more DEN2-specific. Please note our seven mouse monoclonal antibodies against the “E”, “NS1”, “NS3”, and “NS5” proteins that are validated for both ICC/IF and western blot (see below).
 

Dengue Virus Protein Schematic Diagram

 Dengue Virus Protein Schematic Diagram

 

WB analysis of virus-infected BHK21 cells. WB analysis with GeneTex dengue virus antibodies on virus-infected BHK21 cells. (A) mock. (B) virus infection.

 
Dengue virus Capsid protein antibody (GTX124247)

Dengue virus Capsid protein antibody (GTX124247)

ICC/IF analysis of capsid protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 3 virus.
 
Dengue virus prM protein antibody (GTX128092)

Dengue virus prM protein antibody (GTX128092)

ICC/IF analysis of PrM protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 3 virus.
 
Dengue virus Envelope protein antibody (GTX629117)

Dengue virus Envelope protein antibody (GTX629117)

ICC/IF analysis of envelope protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 2 virus.
 
 
Dengue virus NS1 protein antibody (GTX124280)

Dengue virus NS1 protein antibody (GTX124280)

ICC/IF analysis of NS1 protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 2 virus.
 
Dengue virus NS3 protein antibody (GTX629477)

Dengue virus NS3 protein antibody (GTX629477)

ICC/IF analysis of NS3 protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 2 virus.
 
   
 

 

Capsid(GTX103343) prM(GTX128093) Envelope(GTX127277) NS1(GTX124280) NS2B(GTX124246) NS3(GTX124252) NS4A(GTX124249) NS4B(GTX124250) NS5(GTX103350)

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