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登革热病毒研究

登革热病毒研究

Dengue Virus
 
登革热(DEN)是蚊子传播的最严重的病毒性疾病,它是由四种血清型(DEN1-4)中的任何一种的登革热病毒(DENV)引起的,患者对初始感染的血清型具有长期免疫力,然而,不同血清型的顺序感染导致出现严重疾病表现的更大风险,从该观察结果中得出了感染的抗体依赖性增强(ADE)的假说,据此,先前获得的抗DENV抗体似乎可以促进较高的病毒血症和对异型DENV感染作出反应的炎症介质的放大释放,这可以解释流行病学发现,即接受DEN免疫的母亲所生的婴儿患上更严重的临床疾病的风险更高。现在,Ng等人(1)使用小鼠模型系统,提供了有力的证据来支持母子中的ADE假设,他们发现,与未免疫的母亲生产的DENV2感染的小鼠相比免疫DENV1的母亲生产的DENV2感染的小鼠,表现出更严重的疾病并且死亡更快,值得注意的是,概括了流行病学的观察结果,疾病的易感性是年龄依赖性的,总而言之,这种ADE小鼠模型加入了越来越多的传染病动物模型,并将为进一步剖析登革热发病机理的潜在机制提供更多希望与机会。
 
登革热病毒是黄病毒属,具有约10.6 kb的正链RNA基因组,其中包含编码多蛋白的单个开放阅读框,可被细胞和病毒蛋白酶进一步切割成三种结构蛋白(衣壳蛋白C,膜蛋白M ,包膜蛋白E)和七个非结构蛋白(NS1,NS2a,NS2b,NS3,NS4a,NS4b,NS5)。
 
GeneTex提供了一系列DENV蛋白杰出抗体的详尽目录,尽管其中大多数是使用DEN2的重组抗原产生的,极有可能与其他血清型发生交叉反应,但一些抗体仍具DEN2特异性,针对“E” ,“NS1”,“NS3”和“NS5”蛋白的七种小鼠单克隆抗体,均经过ICC / IF和western blot验证(请参见下文)。
 

Dengue Virus Protein Schematic Diagram

 Dengue Virus Protein Schematic Diagram

 

WB analysis of virus-infected BHK21 cells. WB analysis with GeneTex dengue virus antibodies on virus-infected BHK21 cells. (A) mock. (B) virus infection.

 
Dengue virus Capsid protein antibody (GTX124247)

Dengue virus Capsid protein antibody (GTX124247)

ICC/IF analysis of capsid protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 3 virus.
 
Dengue virus prM protein antibody (GTX128092)

Dengue virus prM protein antibody (GTX128092)

ICC/IF analysis of PrM protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 3 virus.
 
Dengue virus Envelope protein antibody (GTX629117)

Dengue virus Envelope protein antibody (GTX629117)

ICC/IF analysis of envelope protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 2 virus.
 
 
Dengue virus NS1 protein antibody (GTX124280)

Dengue virus NS1 protein antibody (GTX124280)

ICC/IF analysis of NS1 protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 2 virus.
 
Dengue virus NS3 protein antibody (GTX629477)

Dengue virus NS3 protein antibody (GTX629477)

ICC/IF analysis of NS3 protein (Dengue virus) antibody on BHK-21 cells infected with Dengue 2 virus.
 
   
 
NS5(GTX103350) NS4B(GTX124250) NS4A(GTX132069) NS3(GTX124252) NS2B(GTX124246) NS1(GTX124280) Envelope(GTX127277) prM(GTX128093) Capsid(GTX103343)
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