形式
Lyophilized powder
存储溶液
Batch dependent (please contact us for details)
存放说明
Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Region/Sequence
N-terminal polyhistidine and GST tag; Met1-Gln355 (AAA36529.1)
表达系统
Baculovirus-Insect Cells
纯度
> 90 % by SDS-PAGE.
内毒素
< 1.0 EU/μg (determined by LAL method)
偶联
Unconjugated
注意事项
仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
别名
protein tyrosine phosphatase non-receptor type 12 , PTP-PEST , PTPG1
细胞定位
Cytoplasm
功能与背景
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
数据库
研究领域
