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用于Omicron研究的抗体和重组蛋白

22-Jul-2022

2021 年 11 月 26 日,WHO 将 SARS-CoV-2 变体 B.1.1.529 指定为第五种关注变体 (VOC),并将其命名为“Omicron”,在其基因组中的 50 多个突变中,至少有 32 个位于棘突蛋白,其中 RBD 有 15 个点突变(图 1);与其他 VOC 一样,在 Omicron 的核蛋白中也发现了突变(图 2);Omicron 分布广泛,胜过 Delta,尽管它似乎会导致更轻微的疾病,但它仍然导致住院人数增加。

The SARS-CoV-2 Omicron Variant Spike Mutation Sites

图 1. Spike mutation sites in Omicron

 

SARS-CoV-2 Omicron Variant Nucleocapsid Mutation Sites

 

图 2. Nucleocapsid protein mutation sites in Omicron

 

GeneTex 提供一系列用于Omicron 研究的重组抗体和蛋白质试剂,值得注意的是,其免疫原不包含任何 Omicron 突变位点的棘蛋白和核蛋白抗体如图 2 所示。请参阅下面的精选产品列表以及表格所选抗体对VOC的反应性。

 

Targeted Region of Spike Antibody Cat. No. Clone BA.1
(GTX136780-pro)
BA.2
(GTX137097-pro)
BA.2.12.1
(GTX137114-pro)
BA.4 / BA.5 (GTX137113-pro)
RBD GTX635807 HL1014
RBD GTX635792 HL1003 X
RBD GTX635793 HL1004 X
S2 GTX632604 1A9
S2 GTX635693 HL237

 

使用指定的 GeneTex 单克隆抗体通过 ELISA(间接或夹心 ELISA)检测源自不同 SARS-CoV-2 变体的重组核衣壳蛋白。

  强检测。 当使用 1μg/ml 蛋白质时,定义为 OD450 值 >1。
  弱检测。 当使用 4μg/ml 蛋白质时,定义为 OD450 值 >1。
X   没有检测。 当使用 4μg/ml 蛋白质时,定义为 OD450 值 <1。

 

精选产品
  
SARS-CoV-2 (COVID-19) Spike (ECD) Protein, Omicron / BA.4 / BA.5 variant, His tag

SARS-CoV-2 (COVID-19) Spike (ECD) Protein, Omicron / BA.4 / BA.5 variant, His tag
(GTX137113-pro)

SARS-CoV-2 (COVID-19) Spike RBD Protein, Omicron / BA.4 / BA.5 variant, His tag

SARS-CoV-2 (COVID-19) Spike RBD Protein, Omicron / BA.4 / BA.5 variant, His tag
(GTX137098-pro)

SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1014]

SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1014]
(GTX635807)

SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1004]

SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1004]
(GTX635793)

侧流分析 (建议的核蛋白兔重组抗体对)
Recombinant Abs Citation Support 

 

抗体对   产品名 克隆性 EC50 目录号
Pair I    Nucleocapsid antibody [HL5511] Rb recAb 14 pM GTX635689
  Nucleocapsid antibody [HL448] Rb recAb 11 pM GTX635686
Pair II   Nucleocapsid antibody [HL5410] Rb recAb 9 pM GTX635685
  Nucleocapsid antibody [HL455] Rb recAb 6 pM GTX635688

 

 

Omicron Spike RBD 和棘蛋白和核蛋白重组蛋白
 
Product Name Expression System Cat. No.
SARS-CoV-2 (COVID-19) Spike RBD Protein, Omicron / BA.2.75 variant, His tag HEK293 cells GTX137422-pro
SARS-CoV-2 (COVID-19) Spike (ECD) Protein, Omicron / BA.2.75 variant, His tag HEK293 cells GTX137533-pro
SARS-CoV-2 (COVID-19) Spike (ECD) Protein, Omicron / BA.1 variant, His tag HEK293 cells GTX136780-pro
SARS-CoV-2 (COVID-19) Nucleocapsid protein, Omicron / BA.1 variant, His tag HEK293 cells GTX136779-pro
SARS-CoV-2 (COVID-19) Spike (ECD) Protein, Omicron / BA.2 variant, His tag HEK293 cells GTX137037-pro
SARS-CoV-2 (COVID-19) Spike (ECD) Protein, Omicron / BA.4 / BA.5 variant, His tag HEK293 cells GTX137113-pro
SARS-CoV-2 (COVID-19) Spike RBD Protein, Omicron / BA.2 variant, His tag HEK293 cells GTX136905-pro
SARS-CoV-2 (COVID-19) Spike RBD Protein, Omicron / BA.1 variant, His tag HEK293 cells GTX136716-pro
SARS-CoV-2 (COVID-19) Spike RBD Protein, Omicron / BA.4 / BA.5 variant, His tag HEK293 cells GTX137098-pro
SARS-CoV-2 (COVID-19) Spike RBD Protein, Omicron / BA.2.12.1 variant, His tag HEK293 cells GTX137249-pro
SARS-CoV-2 (COVID-19) Spike (ECD) Protein, Omicron / BA.2.12.1 variant, His tag HEK293 cells GTX137114-pro
SARS-CoV-2 (COVID-19) Nucleocapsid protein, Omicron / BA.2 / BA.5 variant, His tag HEK293 cells GTX137219-pro
SARS-CoV-2 (COVID-19) Nucleocapsid protein, B.1.1.529 / Omicron variant, His tag E. coli GTX03400-pro

 

 

检测 Omicron 的试剂
 Recombinant Abs Citation Support  Orthogonal Validation

 

Product Name Applications Cat. No.  
SARS-CoV-2 (COVID-19) Nucleocapsid ELISA Pair [HL5511 / HL448] ELISA, Sandwich ELISA GTX500045  
SARS-CoV-2 (COVID-19) Spike RBD ELISA Pair [HL1014 / HL1003] ELISA, Sandwich ELISA GTX500046  
SARS-CoV-2 (COVID-19) Spike RBD Protein Sandwich ELISA Kit ELISA, Sandwich ELISA GTX536267  
SARS-CoV-2 (COVID-19) Spike-ACE2 Binding / Neutralization Assay Kit (Omicron BA.1 / BA.2) Neutralizing/Inhibition GTX537054  Orthogonal Validation
SARS-CoV-2 (COVID-19) Spike RBD antibody WB, ICC/IF, FACS, ELISA, Neutralizing/Inhibition, Sandwich ELISA, IHC-P (cell pellet) GTX135709  
SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] WB, ICC/IF, IHC-P, FACS, IP, ELISA, EM, Sandwich ELISA, IHC-P (cell pellet) GTX632604  
SARS-CoV-2 (COVID-19) Nucleocapsid antibody [HL344] WB, ICC/IF, IHC-P, IHC-Fr, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635679  Recombinant Abs Orthogonal Validation
SARS-CoV-2 (COVID-19) Nucleocapsid antibody [HL5410] WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635685  Recombinant Abs Orthogonal Validation
SARS-CoV-2 (COVID-19) Nucleocapsid antibody [HL448] WB, ICC/IF, IHC-P, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635686  Recombinant Abs Citation Support Orthogonal Validation
SARS-CoV-2 (COVID-19) Nucleocapsid antibody [HL448] (HRP) WB, ELISA, Sandwich ELISA GTX635686-01  Recombinant Abs Citation Support
SARS-CoV-2 (COVID-19) Nucleocapsid antibody [HL453] WB, ICC/IF, ELISA, IHC-P (cell pellet) GTX635687  Recombinant Abs Orthogonal Validation
SARS-CoV-2 (COVID-19) Nucleocapsid antibody [HL455] WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635688  Recombinant Abs Orthogonal Validation
SARS-CoV-2 (COVID-19) Nucleocapsid antibody [HL5511] WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet) GTX635689  Recombinant Abs Citation Support Orthogonal Validation
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL257] WB, ICC/IF, IHC-P, ELISA, IHC-P (cell pellet) GTX635692  Recombinant Abs
SARS-CoV-2 (COVID-19) Spike S2 antibody [HL237] WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635693  Recombinant Abs 
SARS-CoV-2 (COVID-19) Spike S1 antibody [GT263] WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635708  
SARS-CoV-2 (COVID-19) Nucleocapsid antibody [HL455-MS] WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635712  Recombinant Abs Citation Support Orthogonal Validation
SARS-CoV-2 (COVID-19) Spike S1 antibody [HL13402] WB, ICC/IF, ELISA, Sandwich ELISA GTX635713  Recombinant Abs 
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1002] ELISA, Lateral Flow, Neutralizing/Inhibition, Sandwich ELISA GTX635791  Recombinant Abs Citation Support
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1003] ICC/IF, ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635792  Recombinant Abs Citation Support 
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1003] (HRP) ELISA, Sandwich ELISA GTX635792-01  Recombinant Abs 
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1004] ICC/IF, ELISA, Neutralizing/Inhibition, Sandwich ELISA GTX635793  Recombinant Abs
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1004] (HRP) ELISA, Sandwich ELISA GTX635793-01  Recombinant Abs
SARS-CoV-2 (COVID-19) Spike RBD antibody [HL1014] ICC/IF, ELISA, Sandwich ELISA GTX635807  Recombinant Abs 
SARS-CoV-2 (COVID-19) Nucleocapsid antibody [GT113] WB, ICC/IF, ELISA, Sandwich ELISA GTX635808  Orthogonal Validation
SARS-CoV-2 (COVID-19) Spike S2 antibody [HL1038] WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635910  Recombinant Abs
SARS-CoV-2 (COVID-19) Spike S2 / S2' antibody [HL1039] WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX635911  Recombinant Abs
SARS-CoV-2 (COVID-19) Spike S2 antibody [GT745] WB, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX636037  
SARS-CoV-2 (COVID-19) Spike S2 antibody [GT8110] WB, ELISA, Sandwich ELISA, IHC-P (cell pellet) GTX636038  
SARS-CoV-2 (COVID-19) Spike RBD antibody [GT5449] WB, ELISA, Sandwich ELISA GTX636042