SARS-CoV-2 (COVID-19) 抗体和试剂

SARS-CoV-2 (COVID-19) Antibodies and Reagents

侧向流动分析（推荐的抗体对）

Antibody Pair	Product Name	Clonality	EC50	Cat. No.
Pair I	Nucleocapsid antibody [HL5511]	Rb recAb	14 pM	GTX635689
Pair I	Nucleocapsid antibody [HL448]	Rb recAb	11 pM	GTX635686
Pair II	Nucleocapsid antibody [HL5410]	Rb recAb	9 pM	GTX635685
Pair II	Nucleocapsid antibody [HL455]	Rb recAb	6 pM	GTX635688

GeneTex 继续扩展和验证其用于 SARS-CoV-2（COVID-19）研究的优秀抗体和试剂的综合目录，这包括持续评估我们的抗体检测重要病毒变体的能力，尤其是世卫组织指定的关注变体 (VOC)，更多信息，请参阅下面的表 1-2。

在 GeneTex 的 SARS-CoV-2 棘突抗体组合中，抗棘突 RBD [HL1014] 和抗棘突 S1 [HL13402] 重组兔克隆对所有 SARS-CoV-2 棘突蛋白表现出高亲和力，包括 B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), and B.1.617.2 (Delta) 变体（表 1），当与广泛发表的小鼠克隆 [1A9]（针对 S2 亚基）配对进行夹心 ELISA 时，克隆 [HL13402] 也表现异常出色。

GeneTex 的重组兔核衣壳抗体对 WIV04/2019（参考序列）人类细胞表达的全长 SARS-CoV-2 核衣壳蛋白显示出高亲和力，EC50 值范围为 0.006-0.074 nM，重要的是，一对匹配的核衣壳抗体对（即 GTX635689 和 GTX635686）在夹心 ELISA 和侧流检测中表现出卓越的灵敏度，这个抗体对还识别 B.1.617.2 (Delta) 变体的核衣壳蛋白，其他几个单独的重组克隆也是如此（表 2）。

总而言之，GeneTex 的大量 SARS-CoV-2 抗体，保证您会找到适合您所需应用的试剂。

表一、通过 GeneTex 棘蛋白抗体克隆检测 SARS-CoV-2 变异

Targeted Region of Spike	Antibody Cat. No.	Clone	WIV04/2019 (reference sequence)	B.1.351 (Beta)	P.1 (Gamma)	B.1.617.2 (Delta)	B.1.1.529 (Omicron)	BA2 (Omicron)
RBD	GTX635807	HL1014	●	●	●	●	●	●
RBD	GTX635791	HL1002	●	●	●	●	X	X
RBD	GTX635792	HL1003	●	○	○	●	●	○
RBD	GTX635793	HL1004	●	○	●	●	X	○
S1	GTX635713	HL13402	●	●	●	●	X	X
S1	GTX635708	GT263	X	○	X	Not Tested	X	X
S2	GTX632604	1A9	●	●	○	●	○	○
S2	GTX635693	HL237	○	●	X	●	●	●

使用指定的 GeneTex 单克隆抗体，通过间接 ELISA 检测源自不同 SARS-CoV-2 变体的重组棘蛋白（三聚体）。

表二、通过 GeneTex 核衣壳抗体克隆检测 SARS-CoV-2 Delta 变体

Targeted Protein	Antibody Cat. No.	Clone	WIV04/2019 (reference sequence)	B.1.617.2 (Delta)
Nucleocapsid	GTX635686	HL448	●	●
Nucleocapsid	GTX635689	HL5511	●	●
Nucleocapsid	GTX635685	HL5410	●	●
Nucleocapsid	GTX635688	HL455	●	●
Nucleocapsid	GTX635679	HL344	●	●

使用指定的 GeneTex 单克隆抗体通过 ELISA（间接或夹心 ELISA）检测源自不同 SARS-CoV-2 变体的重组核衣壳蛋白。

●		强检测。当使用 1μg/ml 蛋白质时，定义为 OD₄₅₀ 值 >1。
○		弱检测。当使用 4μg/ml 蛋白质时，定义为 OD₄₅₀ 值 >1。
X		没有检测。当使用 4μg/ml 蛋白质时，定义为 OD₄₅₀ 值 <1。

用于 SARS-CoV-2 (COVID-19) 研究的产品的完整列表

Anti-Spike Antibodies

Product Name	Clonality	EC50	Applications	Cat. No.
Spike RBD Omicron antibody [HL1866]	Rb recAb		ELISA, Sandwich ELISA, Neutralizing/Inhibition	GTX637591
Spike RBD Omicron antibody [HL1867]	Rb recAb		ELISA, Sandwich ELISA, Neutralizing/Inhibition	GTX637592
Spike S1 antibody [HL1]	Rb recAb	117 pM	WB, ICC/IF, ELISA, Sandwich ELISA	GTX635656
Spike S1 antibody [HL6]	Rb recAb	251 pM	WB, ICC/IF, IHC-P, FACS, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX635654
Spike S1 antibody [HL134]	Rb recAb	552 pM	WB, ICC/IF, ELISA, IHC-P (cell pellet)	GTX635671
Spike S1 antibody [HL263]	Rb recAb	365 pM	WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX635672
Spike S1 antibody [HL13402]	Rb recAb		WB, ICC/IF, ELISA, Sandwich ELISA	GTX635713
Spike S1 antibody [GT263]	Ms mAb		WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX635708
Spike S1 antibody	Rb pAb		WB, ICC/IF, ELISA	GTX135384
Spike RBD antibody [HL1002]	Rb recAb		ELISA, Lateral Flow, Neutralizing/Inhibition, Sandwich ELISA	GTX635791
Spike RBD antibody [HL1003]	Rb recAb	7.49 pM	ICC/IF, ELISA, Neutralizing/Inhibition, Sandwich ELISA	GTX635792
Spike RBD antibody [HL1003-HU]	Hu recAb		ELISA, Neutralizing/Inhibition, Sandwich ELISA	GTX635866
Spike RBD antibody [HL1004]	Rb recAb	25.13 pM	ICC/IF, ELISA, Neutralizing/Inhibition, Sandwich ELISA	GTX635793
Spike RBD antibody [HL1004] (HRP)	Rb recAb		ELISA, Sandwich ELISA	GTX635793-01
Spike RBD antibody [HL1014]	Rb recAb	28.77 pM	ICC/IF, ELISA, Sandwich ELISA	GTX635807
Spike RBD antibody [HL257]	Rb recAb		WB, ICC/IF, IHC-P, ELISA, IHC-P (cell pellet)	GTX635692
Spike RBD antibody [HL1003] (HRP)	Rb recAb		ELISA, Sandwich ELISA	GTX635792-01
Spike RBD antibody [GT5449]	Ms mAb		WB, ELISA, Sandwich ELISA	GTX636042
Spike RBD antibody	Rb pAb		WB, ICC/IF, FACS, ELISA, Neutralizing/Inhibition, Sandwich ELISA, IHC-P (cell pellet)	GTX135709
Spike RBD antibody	Rb pAb		WB, ICC/IF	GTX135385
Spike S2 antibody [HL237]	Rb recAb		WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX635693
Spike S2 antibody [HL1038]	Rb recAb		WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX635910
Spike S2 antibody [GT745]	Ms mAb		WB, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX636037
Spike S2 antibody [GT8110]	Ms mAb		WB, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX636038
Spike S2 / S2' antibody [HL1039]	Rb recAb		WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX635911
Spike S2 / S2' antibody	Rb pAb		WB, ICC/IF, ELISA, Sandwich ELISA	GTX135386
Spike antibody [1A9]	Ms mAb		WB, ICC/IF, IHC-P, FACS, IP, ELISA, EM, Neutralizing/Inhibition, Sandwich ELISA, IHC-P (cell pellet)	GTX632604
Spike antibody	Rb pAb		WB, ICC/IF, IHC-P, FACS, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX135356
Spike antibody	Rb pAb		WB, ICC/IF, ELISA, Sandwich ELISA	GTX135360
Spike antibody [CR3022]	Hu recAb		ELISA, Neutralizing/Inhibition	GTX01555
Spike antibody [CR3022-RB]	Rb recAb		ELISA, Neutralizing/Inhibition	GTX01556
Spike (N439K Mutant) antibody	Rb pAb		WB	GTX135961
Spike (A222V Mutant) antibody	Rb pAb		WB	GTX135960

| TOP |

Anti-Nucleocapsid Antibodies

Product Name	Clonality	EC50	Applications	Cat. No.
Nucleocapsid antibody [HL455-MS]	Ms mAb		WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX635712
Nucleocapsid antibody [HL5410]	Rb recAb	9 pM	WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet)	GTX635685
Nucleocapsid antibody [HL5410] (Gold)	Rb recAb		Immunoassay	GTX635685-17
Nucleocapsid antibody [HL5511]	Rb recAb	14 pM	WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet)	GTX635689
Nucleocapsid antibody [HL146]	Rb recAb	50 pM	WB, ICC/IF, ELISA, Sandwich ELISA	GTX635680
Nucleocapsid antibody [HL249]	Rb recAb	16 pM	WB, ICC/IF, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX635678
Nucleocapsid antibody [HL344]	Rb recAb	74 pM	WB, ICC/IF, IHC-P, IHC-Fr, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX635679
Nucleocapsid antibody [HL448]	Rb recAb	11 pM	WB, ICC/IF, IHC-P, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet)	GTX635686
Nucleocapsid antibody [HL448] (HRP)	Rb recAb		WB, ELISA, Sandwich ELISA	GTX635686-01
Nucleocapsid antibody [HL453]	Rb recAb	6 pM	WB, ICC/IF, ELISA, IHC-P (cell pellet)	GTX635687
Nucleocapsid antibody [HL455]	Rb recAb	6 pM	WB, ICC/IF, ELISA, Lateral Flow, Sandwich ELISA, IHC-P (cell pellet)	GTX635688
Nucleocapsid antibody [GT113]	Ms mAb		WB, ICC/IF, ELISA, Sandwich ELISA	GTX635808
Nucleocapsid antibody [6H3]	Ms mAb		WB, ICC/IF, IHC-P, IHC-Fr, IP, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX632269
Nucleocapsid antibody	Rb pAb		WB, ICC/IF, IHC-P, IHC-Fr, FACS, IP, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX135357
Nucleocapsid antibody	Rb pAb		WB, ICC/IF, IHC-P, ELISA, Sandwich ELISA, IHC-P (cell pellet)	GTX135361
Nucleocapsid antibody	Rb pAb		WB, ICC/IF, IHC-P (cell pellet)	GTX135570

| TOP |

Other SARS-CoV-2 Antibodies

Product Name	Clonality	Applications	Cat. No.
Envelop antibody	Rb pAb	WB	GTX136046
nsp12 antibody	Rb pAb	WB	GTX135467
nsp12 antibody	Rb pAb	WB, ICC/IF	GTX135469
3CLpro (nsp5) antibody	Rb pAb	WB	GTX135470
3CLpro (nsp5) antibody	Rb pAb	WB	GTX135648
ORF8 antibody	Rb pAb	WB, ICC/IF, ELISA, IHC-P (cell pellet)	GTX135591
nsp1 antibody	Rb pAb	WB, ICC/IF	GTX135586
nsp1 antibody	Rb pAb	WB, ICC/IF, IHC-P (cell pellet)	GTX135612
nsp2 antibody	Rb pAb	WB, ICC/IF	GTX135717
nsp3 / PL-pro antibody	Rb pAb	WB	GTX135796
nsp3 antibody	Rb pAb	WB, ICC/IF, IHC-P (cell pellet)	GTX135589
nsp3 antibody	Rb pAb	WB, ICC/IF	GTX135614
nsp7 antibody	Rb pAb	WB	GTX135728
ORF3a antibody [HL1722]	Rb recAb	WB	GTX637321
ORF7a antibody [3C9]	Ms mAb	WB, ICC/IF	GTX632602
nsp8 antibody [5A10]	Ms mAb	WB, ICC/IF, IHC-Fr, FACS	GTX632696
nsp8 antibody	Rb pAb	WB, IHC-P (cell pellet)	GTX135729
nsp8 antibody	Rb pAb	WB, ICC/IF, IHC-P (cell pellet)	GTX135730
nsp9 antibody	Rb pAb	WB, ICC/IF	GTX135731
nsp9 antibody	Rb pAb	WB, ICC/IF, IHC-P (cell pellet)	GTX135732
nsp10 antibody	Rb pAb	WB, ICC/IF, IHC-P (cell pellet)	GTX135733
nsp10 antibody	Rb pAb	WB, ICC/IF	GTX135734
nsp10 antibody [HL1381]	Rb recAb	WB	GTX636821
nsp15 antibody	Rb pAb	WB, ICC/IF	GTX135737
nsp15 antibody	Rb pAb	WB, ICC/IF	GTX135738
nsp15 antibody [HL1760]	Rb recAb	WB	GTX637410
nsp11 antibody	Rb pAb	WB, ICC/IF	GTX135742

| TOP |

ELISA Antibody Pairs

Product Name	Sensitivity	Cat. No.
Spike RBD ELISA Pair [HL1014 / HL1003]		GTX500046
Spike RBD ELISA pair [HL1014/HL1004]		GTX500047
Spike ELISA Pair [1A9 / HL263]		GTX500041
Spike ELISA Pair [1A9 / HL13402]		GTX500043
Spike ELISA pair [1A9 / HL1003]		GTX500048
Nucleocapsid ELISA Pair [HL5511 / HL448]	39.06 pg/mL	GTX500045
Nucleocapsid ELISA Pair [HL5410 / HL455-MS]	2.68 pg/mL	GTX500042

| TOP |

SARS-CoV-2 ELISA Kit

Product Name	Sensitivity	Applications	Cat. No.
SARS-CoV-2 Membrane Protein Proximity Ligation Assay (PLA) Kit (Cy3)		PLA	GTX537371-23
SARS-CoV-2 (COVID-19) Spike-ACE2 Binding / Neutralization Assay Kit		Neutralizing/Inhibition	GTX536401
Nucleocapsid Protein Sandwich ELISA Kit	18 pg/ml	ELISA, Sandwich ELISA	GTX535824
SARS-CoV-2 (COVID-19) Spike RBD Protein Sandwich ELISA Kit	1.8 pg/ml	ELISA, Sandwich ELISA	GTX536267

| TOP |

Lateral Flow Assay (Recommended Antibody Pairs)

Antibody Pair	Product Name	Clonality	EC50	Cat. No.
Pair I	Nucleocapsid antibody [HL5511]	Rb recAb	14 pM	GTX635689
Pair I	Nucleocapsid antibody [HL448]	Rb recAb	11 pM	GTX635686
Pair II	Nucleocapsid antibody [HL5410]	Rb recAb	9 pM	GTX635685
Pair II	Nucleocapsid antibody [HL455]	Rb recAb	6 pM	GTX635688

| TOP |

Recombinant Proteins

Product Name	Expression System	Applications	Cat. No.
Spike (ECD) protein, His tag (active)	HEK293	Binding Assay, WB, ELISA, Functional Assay, Sandwich ELISA	GTX135972-pro
Spike (ECD) Protein, B.1.1.529 / Omicron variant, His tag	HEK293	Binding Assay, ELISA, Sandwich ELISA	GTX136780-pro
Spike (D614G Mutant) protein (ECD), His tag (active)	HEK293	ELISA, Functional Assay	GTX02575-pro
Spike (ECD) Protein, B.1.1.7 / Alpha variant, His tag (active)	HEK293	ELISA, Functional Assay	GTX136059-pro
Spike (ECD) Protein, B.1.351 / Beta variant, His tag (active)	HEK293	ELISA, Functional Assay, Sandwich ELISA	GTX136061-pro
Spike (ECD) Protein, P.1 / Gamma variant, His tag (active)	HEK293	ELISA, Functional Assay, Sandwich ELISA	GTX136091-pro
Spike (ECD) Protein, B.1.617.2 / Delta variant, His tag (active)	HEK293	ELISA, Sandwich ELISA, Functional Assay	GTX136432-pro
Spike (ECD) Protein, Omicron / BA.2.75 variant, His tag	HEK293	WB, ELISA	GTX137533-pro
Spike S1 Protein, B.1.1.7 / Alpha variant, His tag (active)	HEK293	Functional Assay	GTX136085-pro
Spike S1 Protein, P.1 / Gamma variant, His tag (active)	HEK293	Functional Assay	GTX136094-pro
Spike S1 Protein, B.1.351 / Beta variant, His tag (active)	HEK293	Functional Assay	GTX136095-pro
Spike S1 protein, His and Avi tag (active)	HEK293	ELISA, Functional Assay	GTX01548-pro
Spike S1 protein, His tag (active)	HEK293	ELISA, Sandwich ELISA, Functional Assay	GTX135817-pro
Spike S2 (ECD) protein, mouse IgG Fc tag	HEK293	ELISA, Sandwich ELISA	GTX135684-pro
Spike S2 (ECD) protein, human IgG Fc tag	HEK293	ELISA	GTX01559-pro
Spike S2 Protein, B.1.1.7 / Alpha variant, His tag	HEK293	ELISA, Sandwich ELISA	GTX136023-pro
Spike RBD Protein, BA.2 / Omicron variant, His tag	HEK293	WB, ELISA, Sandwich ELISA	GTX136905-pro
Spike RBD Protein, Omicron / BA.2.75 variant, His tag	HEK293	Binding Assay, WB, ELISA	GTX137422-pro
Spike RBD Protein, B.1.1.529 / Omicron variant, His tag	HEK293	Binding Assay, ELISA, Sandwich ELISA	GTX136716-pro
Spike RBD Protein, B.1.1.7 with E484K, His tag (active)	HEK293	Functional Assay	GTX136058-pro
Spike RBD Protein, B.1.1.7 / Alpha variant, His tag (active)	HEK293	ELISA, Sandwich ELISA, Functional Assay	GTX136014-pro
Spike RBD Protein, B.1.1.7 / Alpha variant, mouse Fc tag (active)	HEK293	ELISA, Functional Assay	GTX136024-pro
Spike RBD Protein, B.1.351 / Beta variant, His tag (active)	HEK293	ELISA, Sandwich ELISA, Functional Assay	GTX136022-pro
Spike RBD Protein, P.1 / Gamma variant, His tag (active)	HEK293	Functional Assay	GTX136043-pro
Spike RBD Protein, B.1.617.2 / Delta variant, His tag (active)	HEK293	ELISA, Functional Assay	GTX136332-pro
Spike RBD Protein, AY.1 / Delta plus variant, His tag	HEK293	Functional Assay	GTX136333-pro
Spike RBD Protein, B.1.1.7 with E484K, His tag (active)	HEK293	ELISA, Functional Assay	GTX136299-pro
Spike RBD Protein, C.37 / Lambda variant, His tag (active)	HEK293 cells	ELISA, Functional Assay	GTX136529-pro
Spike RBD protein, His tag (active)	HEK293	Binding Assay, ELISA, Sandwich ELISA	GTX136090-pro
Nucleocapsid protein, His tag	E. coli	ELISA, Sandwich ELISA	GTX135357-pro
Nucleocapsid protein, His tag	HEK293	ELISA, Sandwich ELISA	GTX135592-pro
Nucleocapsid protein, B.1.1.529 / Omicron variant, His tag	HEK293	WB, ELISA, Sandwich ELISA	GTX136779-pro
Envelope protein, His and Avi tag	E. coli		GTX01547-pro
Envelope Protein, GST and His Tag	HEK293		GTX01565-pro
3CLpro (nsp5) protein, His tag	E. coli		GTX135648-pro
3CLpro (nsp5) protein, His and Avi tag	E. coli		GTX01557-pro
PL-pro, His tag (active)	E.coli	Functional Assay	GTX03563-pro

| TOP |

Cell Pellet Blocks / Slides

Product Name	Applications	Cat. No.
Spike FFPE 293T cell pellet block	IHC-P, IHC-P (cell pellet)	GTX435640
Spike S1 FFPE 293T cell pellet block	IHC-P (cell pellet)	GTX435643
Spike S2 FFPE 293T cell pellet block	IHC-P (cell pellet)	GTX435644
Nucleocapsid FFPE 293T cell pellet block	IHC-P, IHC-P (cell pellet)	GTX435641
Envelope FFPE 293T cell pellet block	IHC-P (cell pellet)	GTX435642
Membrane FFPE 293T cell pellet block	IHC-P (cell pellet)	GTX435645
Spike FFPE 293T cell pellet slide	IHC-P (cell pellet)	GTX435744

| TOP |

Overexpression Lysates

Product Name	Applications	Cat. No.
Spike overexpression 293T whole cell lysate	WB, ELISA	GTX535664
Spike S1 overexpression 293T whole cell lysate	WB	GTX535663
Nucleocapsid overexpression 293T whole cell lysate	WB, ELISA	GTX535665

| TOP |

Products for Host Cell Entry Research

Product Name	Clonality or Expression System	Applications	Cat. No.
ACE2 antibody [GT19410]	Ms mAb	WB, IHC-P, ELISA, Sandwich ELISA	GTX635897
ACE2 antibody [N1N2], N-term	Rb pAb	WB, ICC/IF, IHC-P, FACS, ELISA	GTX101395
ACE2 antibody [SN0754]	Rb recAb	WB, ICC/IF, IHC-P	GTX01160
ACE2 antibody	Rb pAb	WB, ICC/IF, IHC-P, ELISA	GTX15349
Human ACE2(ECD) protein, mouse IgG Fc tag	HEK 293	ELISA, Functional Assay	GTX135683-pro
Human ACE2 protein, His and Avi tag	HEK 293	ELISA, Functional Assay	GTX01550-pro
TMPRSS2 antibody [N2C3]	Rb pAb	WB, IHC-P	GTX100743
Camostat mesylate		TMPRSS2 inhibitor	GTX01523