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新冠病毒研究 重组抗体现正供应中

30-Sep-2020
spike protein / Nucleocapsid protein

 

GeneTex应用独家的重组抗体生产平台,开发出针对新冠病毒刺突和核衣壳蛋白的重组抗体,扩大了SARS-CoV-2研究相关抗体和试剂的产品线,四个S1抗体对SARS-CoV-2的蛋白具特异性,且不与SARS-CoV或MERS-CoV的刺突蛋白起交叉反应,特别是克隆[HL1]与[HL6]对哺乳动物表达的刺突蛋白显示出高度亲和力,其EC50值分别为0.117 nM和0.251 nM,当与GeneTex的鼠单抗[1A9]配对进行夹心ELISA分析时,两个克隆的抗体表现都非常出色,此外,尽管冠状病毒核衣壳蛋白之间具有高度同源性,但GeneTex的核衣壳重组抗体[HL344]对SARS-CoV-2具特异性,且不与SARS-CoV或MERS-CoV的核衣壳蛋白起交叉反应,所有八个核衣壳重组抗体对哺乳类动物表达的全长SARS-CoV-2核衣壳蛋白表现出高度亲和力(EC50值介于0.006-0.074 nM之间)。

 

Full Listing of Products for SARS-CoV-2 (COVID-19) Research

Anti-Spike antibodies

Recombinant Citation-Support Protein Overexpression 

  Product Name Clonality EC50 or Sensitivity Applications Cat. No.
Spike S1 antibody [HL1] Rb recAb 0.117 nM WB, ICC/IF, ELISA, Sandwich ELISA GTX635656
Spike S1 antibody [HL6] Rb recAb 0.552 nM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA, FACS, IHC-P GTX635654
Spike S1 antibody [HL134] Rb recAb 0.251 nM WB, ICC/IF, IHC-P (cell pellet), ELISA GTX635671
Spike S1 antibody [HL263] Rb recAb 0.672 nM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635672
Spike S1 antibody [HL13402] Rb recAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX635713
Spike S1 antibody [GT263] Ms mAb   WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635708
  Spike S1 antibody Rb pAb   WB, ICC/IF, ELISA GTX135384
Spike RBD antibody [HL1003] Rb recAb 7.49 pM ICC/IF, ELISA, Neutralizing/Inhibition GTX635792
Spike RBD antibody [HL1004] Rb recAb 25.13 pM ICC/IF, ELISA, Sandwich ELISA, Neutralizing/Inhibition GTX635793
Spike RBD antibody [HL1014] Rb recAb 28.77 pM ICC/IF, ELISA GTX635807
Spike RBD antibody [HL257] Rb recAb   WB, ICC/IF, IHC-P (cell pellet), ELISA GTX635692
  Spike RBD antibody Rb pAb   WB, FACS, Neutralizing/Inhibition, ICC/IF, ELISA, IHC-P (cell pellet) GTX135709
  Spike RBD antibody Rb pAb   WB, ICC/IF GTX135385
Spike S2 antibody [HL237] Rb recAb   WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635693
  Spike S2 / S2' antibody Rb pAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX135386
Spike antibody [1A9] Ms mAb   WB, ICC/IF, IHC-P, IHC-P (cell pellet), FACS, IP, ELISA, Sandwich ELISA GTX632604
  Spike antibody Rb pAb   WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX135356
  Spike antibody Rb pAb   WB, ICC/IF, ELISA, Sandwich ELISA GTX135360
Spike antibody [CR3022] Hu recAb   ELISA, Neutralizing/Inhibition GTX01555
Spike antibody [CR3022-RB] Rb recAb   ELISA, Neutralizing/Inhibition GTX01556

 

Anti-Nucleocapsid antibodies

Recombinant Citation-Support Protein Overexpression 

  Product Name Clonality EC50 or Sensitivity Applications Cat. No.
Nucleocapsid antibody [HL455-MS] Ms mAb 2.68 pg/mL WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635712
Nucleocapsid antibody [HL5410] Rb recAb 0.009 nM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635685
Nucleocapsid antibody [HL5410] (Gold) Rb recAb   Immunoassay GTX635685-17
Nucleocapsid antibody [HL5511] Rb recAb 0.014 nM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635689
Nucleocapsid antibody [HL146] Rb recAb 0.05 nM WB, ICC/IF, ELISA, Sandwich ELISA GTX635680
Nucleocapsid antibody [HL249] Rb recAb 0.016 nM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635678
Nucleocapsid antibody [HL344] Rb recAb 0.074 nM WB, ICC/IF, IHC-P, IHC-P (cell pellet), IHC-Fr, ELISA, Sandwich ELISA GTX635679
Nucleocapsid antibody [HL448] Rb recAb 0.011 nM WB, ICC/IF, IHC-P, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635686
Nucleocapsid antibody [HL448] (HRP) Rb recAb 39.06 pg/mL ELISA, Sandwich ELISA, WB GTX635686-01
Nucleocapsid antibody [HL453] Rb recAb 0.006 nM WB, ICC/IF, IHC-P (cell pellet), ELISA GTX635687
Nucleocapsid antibody [HL455] Rb recAb 0.006 nM WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX635688
  Nucleocapsid antibody [GT113] Ms mAb   WB GTX635808
Nucleocapsid antibody [6H3] Ms mAb   WB, ICC/IF, IHC-P (cell pellet), IP, ELISA, Sandwich ELISA GTX632269
Nucleocapsid antibody Rb pAb   WB, ICC/IF, IHC-P, IHC-P (cell pellet), FACS, IP, ELISA, Sandwich ELISA GTX135357
  Nucleocapsid antibody Rb pAb   WB, ICC/IF, IHC-P (cell pellet), ELISA, Sandwich ELISA GTX135361

 

Other Antibodies

Citation-Support  

  Product Name Clonality Applications Cat. No.
  RdRp (nsp12) antibody Rb pAb WB, ICC/IF GTX135467
  RdRp (nsp12) antibody Rb pAb WB GTX135469
  ORF8 antibody Rb pAb WB, ICC/IF GTX135591
  nsp1 antibody Rb pAb WB GTX135586
  nsp1 antibody Rb pAb WB, ICC/IF GTX135612
  PLpro (nsp3) antibody Rb pAb WB, ICC/IF GTX135589
  PLpro (nsp3) antibody Rb pAb WB, ICC/IF GTX135614
ORF7a antibody [3C9] Ms mAb WB, ICC/IF GTX632602
NSP8 antibody [5A10] Ms mAb WB, ICC/IF, FACS GTX632696

 

ELISA Pairs

Product Name Cat. No.
Spike ELISA Pair - [1A9 / HL263] GTX500041
Spike ELISA Pair - [1A9 / HL6] GTX500040
Spike ELISA Pair [1A9 / HL13402] GTX500043
Nucleocapsid ELISA Pair [HL5511 / HL448] GTX500045
Nucleocapsid ELISA Pair [HL5410 / HL455-MS] GTX500042

 

Lateral Flow Recommended Pairs  

Recombinant 

Pair   Product Name Clonality EC50 Cat. No.
Pair I Nucleocapsid antibody [HL5511] Rb recAb 0.014 nM GTX635689
Nucleocapsid antibody [HL448] Rb recAb 0.011 nM GTX635686
Pair II Nucleocapsid antibody [HL5410] Rb recAb 0.009 nM GTX635685
Nucleocapsid antibody [HL455] Rb recAb 0.006 nM GTX635688

 

Recombinant Proteins

Product Name Expression System Applications Cat. No.
Spike S1 protein, His tag (active) HEK293 ELISA, Functional Assay GTX01554-pro
Spike S1 protein, His and Avi tag (active) HEK293 ELISA, Functional Assay GTX01548-pro
Spike S1 protein, His tag (active) HEK293 WB, ELISA, Functional Assay, Sandwich ELISA GTX135817-pro
Spike S2 (ECD) protein, mouse IgG Fc tag HEK293 WB, ELISA, Sandwich ELISA GTX135684-pro
Spike S2 (ECD) protein, human IgG Fc tag HEK293   GTX01559-pro
Spike RBD protein, His tag (active) HEK293 Functional Assay GTX01546-pro
Nucleocapsid protein, His tag E. coli ELISA, Sandwich ELISA GTX135357-pro
Nucleocapsid protein, His tag HEK293 WB, ELISA, Sandwich ELISA GTX135592-pro
Nucleocapsid protein,His tag (Gold) HEK293 Immunoassay GTX135746-pro
Envelope protein, His and Avi tag E. coli   GTX01547-pro
Envelope Protein, GST and His Tag HEK293   GTX01565-pro
3CLpro (nsp5) protein, His tag E. coli WB GTX135648-pro
3CLpro (nsp5) protein, His and Avi tag E. coli   GTX01557-pro

 

Cell Pellet Blocks

Product Name Applications Cat. No.
Spike FFPE 293T cell pellet block IHC-P (cell pellet) GTX435640
Spike S1 FFPE 293T cell pellet block IHC-P (cell pellet) GTX435643
Spike S2 FFPE 293T cell pellet block IHC-P (cell pellet) GTX435644
Nucleocapsid FFPE 293T cell pellet block IHC-P (cell pellet) GTX435641
Envelope FFPE 293T cell pellet block IHC-P (cell pellet) GTX435642
Membrane FFPE 293T cell pellet block IHC-P (cell pellet) GTX435645

 

Overexpression Lysates

Product Name Applications Cat. No.
Spike overexpression 293T whole cell lysate WB, ELISA GTX535664
Spike S1 overexpression 293T whole cell lysate WB GTX535663
Nucleocapsid overexpression 293T whole cell lysate WB, ELISA GTX535665
Spike overexpression 293T whole cell lysate WB GTX535668

 

Products for Host Cell Entry Research

Recombinant Citation-Support KOKD-Validation Protein Overexpression

  Product Name Clonality or Expression System Applications Cat. No.
ACE2 antibody [N1N2], N-term Rb pAb WB, ICC/IF, IHC-P, FACS, ELISA GTX101395
ACE2 antibody [SN0754] Rec Rb pAb WB, ICC/IF, IHC-P GTX01160
  ACE2 antibody Rb pAb WB, ICC/IF, IHC-P, ELISA GTX15349
  Human ACE2(ECD) protein, mouse IgG Fc tag HEK 293 WB, ELISA, Functional Assay GTX135683-pro
  Human ACE2 protein, His and Avi tag HEK 293 ELISA GTX01550-pro
  TMPRSS2 antibody [N2C3] Rb pAb WB, IHC-P GTX100743
  TMPRSS2 antibody, Internal Rb pAb WB, FACS GTX81494
  Camostat mesylate   TMPRSS2 inhibitor GTX01523

 

Featured Antibodies

Recombinant
Spike S1 antibody [HL6] (GTX635654)

Spike S1 antibody [HL6] (GTX635654)

Nucleocapsid antibody Nucleocapsid antibody [HL5410] (Gold) (GTX635685-17)

Nucleocapsid antibody [HL5410] (Gold) (GTX635685-17)

Spike S1 antibody [HL263] (GTX635672)

Spike S1 antibody [HL263] (GTX635672)

Nucleocapsid antibody [HL448] (GTX635686)

Nucleocapsid antibody [HL448] (GTX635686)

 

Highlighted ELISA Pairs

Nucleocapsid ELISA Pair [HL5410 / HL455-MS] (GTX500042)

Nucleocapsid ELISA Pair [HL5410 / HL455-MS] (GTX500042)

Nucleocapsid ELISA Pair [HL5511 / HL448] (GTX500045)

Nucleocapsid ELISA Pair [HL5511 / HL448] (GTX500045)

Spike ELISA Pair [1A9 / HL6] (GTX500040)

Spike ELISA Pair [1A9 / HL6] (GTX500040)

Spike ELISA Pair [1A9 / HL263] (GTX500041)

Spike ELISA Pair [1A9 / HL263] (GTX500041)

 

Highlighted Proteins

Spike S2 (ECD) protein, mouse IgG Fc tag (GTX135684-pro)

Spike S2 (ECD) protein, mouse IgG Fc tag (GTX135684-pro)

Spike RBD protein, His tag (active) (GTX01546-pro)

Spike RBD protein, His tag (active) (GTX01546-pro)

Nucleocapsid protein,His tag (Gold) (GTX135746-pro)

Nucleocapsid protein,His tag (Gold) (GTX135746-pro)

Envelope protein, His and Avi tag (GTX01547-pro)

Envelope protein, His and Avi tag (GTX01547-pro)